16. Des Moines, Iowa
Des Moines is the capital of Iowa, a state known for colleges (the University of Iowa, Iowa State and Drake, among others), campers (Winnebago is based here), corn (Iowa produces more than any other state) and climate extremes.
In January, the average low temperature in Des Moines is a brutal 14 degrees Fahrenheit. Summers are no picnic either: The average high in July is 86, and long-time residents say if the humidity doesn’t get you, the mosquitoes will.
The unforgiving weather is a major reason people leave here, despite the availability of jobs (unemployment was just 2.2% in April) and the inexpensive home prices ($154,000, on average).